汪惠丽

发布日期:2015-11-10

   教师简介:
 姓 名:  汪惠丽
 职 称:  教授
 职 务:

 博士生导师、食品工程系主任

 所属系:  
 邮 箱:   wanghl@hfut.edu.cn
 电 话:   0551-62919397
   个人简历:
汪惠丽,合肥工业大学食品科学与工程学院教授,博士生导师,食品科学与工程系系主任。教育部“新世纪优秀人才”,“黄山青年学者”,安徽省食品安全委员会专家组成员。美国神经科学学会会员,中国毒理学会会员,中国毒理学会神经毒理专业委员会青年委员,安徽省预防医学学会卫生毒理专业委员会副主任委员,安徽省神经科学学会理事,安徽省环境诱变剂学会理事。2006 年毕业于中国科学技术大学生命科学学院,获理学博士学位。2006 年12 月至2007 年3 月参加中国第二十三次南极科学考察队,赴南极长城站考察。2008年至2011年,留学美国加州大学伯克利分校(University of California, Berkeley)和斯坦福大学医学院。从事铅及环境因素的神经毒理学和环境毒理学、食品安全与营养的教学和研究。现主持国家重点基础研究计划973课题,国家自然科学基金面上项目、青年基金,教育部博导类课题等项目多项。2007年获教育部自然科学二等奖,2014年荣获陕西省科学技术奖一等奖和中国毒理学会全国青年科技奖。多次参加国际、国内学术会议,先后于2009 年在美国冷泉港(Cold Spring Harbor)国际会议中心、2011 年在Washington DC 国际神经科学年会(Society of Neuroscience)作大会报告,2013年在广州全国第六届毒理学大会分会场报告,2015年在韩国济州岛第七届亚太毒理学大会上受邀任分会主席并作大会报告,已发表SCI 论文40余篇,一些论文发表在生物科学领域重要杂志如”Proceedings of the National Academy of Sciences of the United States of America”; ”Journal of Neuroscience”(featured article);”Environmental Health & Perspectives”; “European Journal of Neuroscience”;“Toxicology Letters”上。其中,2011 年以”featured article”发表在”The Journal of Neuroscience”上的文章”Decrease in Calcium Concentration Triggers Neuronal Retinoic Acid Synthesis during Homeostatic Synaptic Plasticity”被国际著名的Faculty of 1000 评为“must read”论文。
   主要研究领域、方向:

领域:分子营养和食品安全的基础和应用研究:

1)  食品营养成分神经保护作用及机理;

2)  食品营养成分安全性评价及毒理学研究,营养素和营养素物质的安全剂量,过量时的毒理作用以及分子机制;

3)  食物中有毒有害物质对神经系统的损伤作用及其代谢途径和致病机理,食品安全风险评估、预防控制和检测新技术研究。

   开设课程:
《食品质量与安全专业导论》、《食品毒理学》、《食品卫生学》
   近年的科研项目、专著与论文、专利、获奖:
代表性论文

1.Hui-Li Wang, Xiang-Tao Chen, Bin Yang, Fang-Li Ma, Shu Wang, Ming-Liang Tang, Ming-Gao Hao, Di-Yun Ruan, Case-Control Study of Blood Lead Levels and Attention-Deficit Hyperactivity Disorder in Chinese Children, Environmental Health Perspectives, 2008, 116 (10):1401-1406 (5年影响因子: 7.607)

2.Hui-Li Wang, Zhenjie Zhang, MaikHintze, Lu Chen. Decrease in Calcium Concentration Triggers Neuronal Retinoic Acid Synthesis during Homeostatic Synaptic Plasticity.The Journal of Neuroscience, 2011, 31(49): 17764-17771(5年影响因子: 7.648)

3.Hastie, P., Ulrich, M., Wang, H., Arant, R.J., Lau, A.G., Zhang, Z., Isacoff, E.Y. and Chen, L. (2013). AMPA Receptor/TARP stoichiometry visualized by single molecule subunit counting. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110(13):5163-5168(5年影响因子: 10.727)

4.Yi Xu, Xiang-Tao Chen, Man Luo, Yuqing Tang, Guangxiang Zhang, De Wu, Bin Yang, Di-Yun Ruan, Hui-Li Wang*. ( 2015) Multiple epigenetic factors predict the Attention Deficit/Hyperactivity Disorder among the Chinese Han children. Journal of Psychiatric Research, 2015, 64: 40-50. (5年影响因子: 4.46)

5.Zhi-Hua Liu, Ye Yang, Meng-Meng Ge, Li Xu, Yuqing Tang, Fan Hu, Yi Xu, Hui-Li Wang*.( 2015) Bisphenol-A Exposure Alters Memory Consolidation and Hippocampal CA1spine formation through Wnt Signaling In Vivo and In Vitro. Toxicology Research, 2015, 4: 686 – 694(5年影响因子: 3.983)

6.Meng-Meng Ge, Fan Hu, Zhi-Yi Lou, WeizhenXue, Hang Yu, Li Xu, Zhi-Hua Liu, Yi Xu, Xiang-Tao Chen*, Hui-Li Wang.* (2015) Role of Wnt/-catenin signaling in the protective effect of epigallocatechin-3-gallate on lead induced impairments of spine formation in the hippocampus of rats. RSC Advances, 2015,5: 31622–31628 (5年影响因子:3.708)

7.Yang Du, Meng-Meng Ge, WeizhenXue, Qian-Qian Yang, Shuang Wang, Yi Xu, Hui-Li Wang*. (2015)Chronic Lead Exposure and Mixed Factors of Gender×Age×Brain Regions Interactions on Dendrite Growth, Spine Maturity and NDR Kinase. Plos One, 2015, DOI:10.1371/journal.pone.0138112(5年影响因子: 4.015)

8.Fan Hu, Li Xu, Zhi-Hua Liu, Meng-Meng Ge, Di-Yun Ruan and Hui-Li Wang*.(2014) Developmental lead exposure alters synaptogenesis through inhibiting canonical Wnt pathwayin vivo and in vitro. Plos One, 2014, DOI: 10.1371/journal.pone.0101894(5年影响因子: 4.015)

9.Man Luo, Yi Xu, RongCai, Yu-Qing Tang, Meng-Meng Ge, Zhi-Hua Liu, Li Xu, Fan Hu, Di-Yun Ruan, Hui-Li Wang*.(2014) Epigenetic Histone Modification Regulates Developmental Lead Exposure Induced Hyperactivity in Rats. Toxicology Letters, 2014, 225:78-85. (5年影响因子: 3.706)

10.Hui-Li Wang, Xiang-Tao Chen, Le Luo, et al. Reparatory Effects of Nicotine on NMDA Receptor-mediated Synaptic Plasticity in the Hippocampal CA1 Region of Chronically Lead-exposed Rats. European Journal of Neuroscience, 2006,23:1111-1119 (5年影响因子: 3.928)

11.Yi Xu , TingWang, Jian Kong, Hui-Li Wang. (2015)Identification and functional characterization of AclB, a novel cell-separating enzyme from Lactobacillus casei. International Journal of Food Microbiology 203 (2015) 93–100.

12.LIU Zhi-hua, Wang Hui-li, Wu Sheng, LIU Yang, CHEN Xiang-tao, Developmental bisphenol-A exposure affects hippocampal dentate gyrus area spine formation through Wnt/β-catenin signaling. Chin.J. Parmacol. Toxicol. 2014. 28(2):161-167

13.Li Xu, Hui-li Wang*, Chun-yan Wu, Ming-hua Zhou and Ya-yun Wang. Study on Optimization of Extraction Technology for Bitter Melon SeedOil by Supercritical CO2. Applied Mechanics and Materials Vol. 618 (2014) pp 354-361

14.Shengxiong Huang, Jian Ding, Dejing Deng…Hui-Li wang, Hongkun Zheng, ZhangjunFei&Yongsheng Liu. (2013) Draft genome of the kiwifruit Actinidiachinensis. Nature Communications. 2013 Oct 18;4:2640. doi: 10.1038/ncomms3640.

15.Hui-Li Wang, Xiang-Tao Chen, Shu-Ting Yin, Chuan-Yun Wu, Ming-Liang Tang, Di-Yun Ruan,Opposite Effects of α-Lipoic Acid on Antioxidation and Long Term Potentiation in Control and Chronically Lead-exposed Rats, Naunyn-Schmiedeberg’s Archives of Pharmacology, 2008, 378:303-310

16.Chuanyun Wu, Bing Liu, Hui-Li Wang, Di-Yun Ruan. Levothyroxine rescues the lead-induced hypothyroidism and impairment of long-term potentiation in hippocampal CA1 region of the developmental rats. Toxicology and Applied Pharmacology, 2011, 256 (2): 191-197

17.Hao Sun, Hui-Li Wang, Shu Wang. d-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro, Neuroscience Letters 417 (2007) 118–122

18.Shu Wang, Pu Hu, Hui-Li Wang, Ming Wang, Ju-Tao Chen, Jiu-Lai Tang, Di-Yun Ruan Effects of Cd2+ on AMPA receptor-mediated synaptic transmission in rat hippocampal CA1 area, Toxicology Letters, 2008, 176(3): 215-222

19.Tang M, Xin T, Zeng J, Wang H, Li C, Yin S, Yan D, Deng H, Liu J, Wang M, Chen J, Ruan DY.Unmodified CdSe Quantum Dots Induced Elevation of Cytoplasmic Calcium Levels and Impairment of Functional Properties of Sodium Channels in Rat Primary Cultured Hippocampal Neurons,Environ Health Perspect: 2008, 116(7):915-922.

20.Mingliang Tang, Ming Wang, Tairan Xing, Jie Zeng, Huili Wang, Di-Yun Ruan. Mechanisms of Unmodified CdSe Quantum Dot-Induced Elevation of Cytoplasmic Calcium Levels in Primary Cultures of Rat Hippocampal Neurons. Biomaterials, 2008, 29 (33) :4383-4391

21.Shu Wang, Yan Gu,Hui-Li Wang, et al. Inhibitory Effect of Cd2+ on Glycine-induced Chloride Current in Rat Hippocampal Neurons, Brain Research Bulletin, 2006, 69: 680–686

22.Xiang-Tao Chen, Jun Li, Hui-Li Wang, et al. Immunomodulating Effects of Fractioned Polysaccharides Isolated from Yu-Ping-Feng-Powder in Cyclophosphamide-Treated Mice. American Journal of Chinese Medicine, 2006, 34 (4): 631-641

23.Chenchen Li , Xinmei Li , Weiheng Chen , Shanshan Yu , Jutao Chen , Huili Wang and DiyunRuan The different roles of cyclinD1-CDK4 in STP and mGluR-LTD during the  postnatal development in mice hippocampus area CA1,BMC Developmental Biology, 2007, 7(1):57

24.Shan-Shan Yu, Ming Wang, Xin-Mei Li, Wei-Heng Chen, Ju-Tao Chen, Hui-Li Wang and Di-Yun Ruan, Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure, BMC Developmental Biology, 2007, 7(1):51

25.Li Su, Ming Wang, Shu-Ting Yin,Hui-Li Wang, Liang Chen, Li-Guang Sun, Di-Yun Ruan., The interaction of selenium and mercury in the accumulations and oxidative stress of rat tissues. Ecotoxicology and Environmental Safety. 2008, 70:483-489

26.Pu Hu , Lei Sun , Zhi-Qiang Zhu , Shu Wang , Shan-Shan Yu , Ping Zhang, Ming Wang, Hui-Li Wang, Li-wen Niu, Mai-kun Teng, Di-Yun Ruan, Crystal structure and electrophysiological characterization of Natratoxin, a novel snake sPLA2 neurotoxin inhibiting A-type K+ currents, PROTEINS: Structure, Function, and Bioinformatics, 2008,  72(2):673-683

27.Chenchen Li, Tairan Xing, Mingliang Tang, Wu Yong, Dan Yan, Hongmin Deng, Huili Wang, Ming Wang, Jutao Chen, and DiyunRuan*, Involvement of cyclinD1/CDK4 and pRb mediated by PI3K/AKT pathway activation in Pb2+-induced neuronal death in cultured hippocampal neurons, Toxicology and Applied Pharmacology, 2008, 229:351-361

28.Dan Yan, Lang Wang, Fang-li Ma, Hongmin Deng, Jin Liu, Chenchen Li, Huili Wang, Jutao Chen, Jiu-Lai Tang and Di-Yun Ruan,  Developmental exposure to lead causes inherent changes on voltage-gated sodium channels in rat hippocampal CA1 neurons, Neuroscience, 2008, 153:436-445

29.Shu Wang, Tai-Ran Xing, Ming-Liang Tang, Wu Yong, Chen-Chen Li, Liang Chen, Hui-Li Wang, Jiu-Lai Tang, Di-Yun Ruan*, Effects of Cd2+ on transient outward and delayed rectifier potassium currents in acutely isolated rat hippocampal CA1 neurons. Naunyn-Schmiedeberg Archives of Pharmacology, 2008, 377:245-253.

30.Shu-Ting Yin; Ming-Liang Tang; Li Su; Liang Chen; Pu Hu; Hui-Li Wang; Ming Wang;  Effects of Epigallocatechin-3-gallate on lead-induced oxidative damage,Toxicology. 2008, 249(1): 45-54

31.Pu Hu, Ming Wang, Wei-Heng Chen, Ji Liu, Liang Chen, Shu-Ting Yin, Wu Yong, Ju-Tao Chen, Hui-Li Wang, Jiu-Lai Tang, and Di-Yun Ruan. Protective effects of Quercetin against lead-induced impairment of synaptic plasticity in hippocampal Dentate Gyrus of rats in vivo, Naunyn-Schmiedeberg’s Archives of Pharmacology, 2008, 378(1):43-51.

32.Dan Yan, Lang Wang, Fang-li Ma$ ,Hongmin Deng, Jin Liu, Chenchen Li, Huili Wang, Jutao Chen, Di-Yun Ruan, Developmental exposure to lead causes inherent changes on voltage-gated sodium channels in rat hippocampal CA1 neurons, Neuroscience, 2008, 153: 436-445

33.Ming-Liang Tang,Le Luo, Da-Miao Zhu, Hui-Li Wang, Yun-Yun Luo, Di-Yun Ruan*, Muscarinic Cholinergic Modulation of Synaptic Transmission and Plasticity in Rat Hippocampus following Chronic Lead Exposure. Naunyn-Schmiedeberg  Archives of Pharmacology,Naunyn-Schmiedeberg Archives of Pharmacology,379(1):37-45,-2009

34.Zhao QH, Zhang Y, Liu Y, Wang HL,Shen YY, Yang WJ, Wen LP. Anticancer effect of realgar nanoparticles on mouse melanoma skin cancer in vivo via transdermal drug delivery. Med Oncol, 2009 (DOI 10.1007/s12032-009-9192-1)

35.Wu Yong, Tai-Ran Xing, ShuWang, Liang Chen, Pu Hu, Chen-ChenLi, Hui-li Wang, Ming Wang, Ju-Tao Chen, Di-Yun Ruan.Protective Effects of Gastrodin on Lead-Induced Synaptic Plasticity Deficits in Rat Hippocampus.Planta Med, 2009,75(10):1112-7 

著作

1. 《食品毒理学》,合肥工业大学出版社 主编

2. 《神经生物学》,中国科学技术大学出版社 编委

3. 《医学科研入门》,人民卫生出版社 编委

4. 《临床毒理学》,人民卫生出版社 编委

5. 《神经毒理学》,人民卫生出版社 编委

在研项目

1.  国家“973”计划课题  铅暴露影响脑发育的细胞分子机制 (No.2012CB525003)  主持,课题负责人

2.  国家自然科学基金面上项目 铅暴露对大鼠海马神经环路形成的影响及突触稳态调控机制(21477031)  主持人

3.  国家自然科学基金青年基金 全反式维甲酸对神经元网络的稳态可塑性钙调控作用及机理 (31200851) 主持人

4.  教育部新世纪优秀人才支持计划(NCET-12-0835)主持人

5.  教育部博士点基金博导类课题  MEA微电极阵列技术研究铅损伤学习记忆功能的神经网络机制 (No. 20130111110024) 主持人

6.  合肥工业大学人才引进启动基金(407-037030) 主持人


荣誉、奖励及参加学术团体的情况

科技奖项

1.  陕西省自然科学技术奖一等奖     2014年

2.  中国毒理学会全国优秀青年科技奖  2014年

3.  第六届全国毒理学大会优秀论文奖  2013年

4.  教育部新世纪优秀人才支持计划    2012年

5.  安徽省第六届自然科学优秀学术论文一等奖(安徽省科协、人力资源厅、社会保障厅) 2010年

6.教育部自然科学奖二等奖  2007年

7.  合肥工业大学巾帼标兵 2013年

8.指导的研究生、本科生多次荣获国家奖学金和优秀毕业论文

学术团体

安徽省预防医学学会卫生毒理专业委员会副主任委员

美国神经科学学会会员

中国毒理学会会员

中国毒理学会神经毒理专业委员会青年委员

安徽省神经科学学会理事

安徽省环境诱变剂学会理事