苗敏

发布日期:2016-06-23

苗敏

博士,讲师

个人简历

1 教育经历

2010,10-2012,12,美国爱达荷大学(University of Idaho),农业与生命科学学院,植物病理学, 联合培养博士

2009,9-2010,9,四川大学,生命科学学院,生物化学与分子生物学,博士

2006,9-2009,7,四川大学,生命科学学院,生物化学与分子生物学,硕士

2 科研学术经历

2015,11-至今,合肥工业大学,食品科学与工程学院,讲师

2013,1-2015,10,合肥工业大学,食品科学,博士后

主要研究领域与方向

1.  研究调控番茄果实品质的分子机制,包括番茄果实色素的积累,番茄果实大小的调控。

2. 研究植物抗病信号传到的途径,细胞对病原菌的响应过程中的重要调控分子。

开设课程

《酶与蛋白质工程》《生物技术导论》

代表性论文、著作与专利

1. Miao M*, Niu X*, Kud J*, Du X, Avila J, Devarenne T, Kuhl J, Liu Y, Xiao F. The ubiquitin ligase SEVEN IN ABSENTIA (SINA) ubiquitinates a defense-related NAC transcription factor and is involved in defense signaling. New phytologist. 2016, doi: 10.1111/nph.13890. (IF)

2. Li Y*, Deng H*, Miao M*, Li H, Huang S, Wang S, Liu Y. Tomato MBD5, a mehy CpG binding domain protein, physically interacts with UV-damaged DNA Binding Protein-1 and function in multiple processes. New phytologist. 2016, 210(1):208-226. (*共同第一作者)

3. Tang X*, Miao M*, Niu X*, Zhang D, Cao X, Jin X, Zhu Y, Fan Y, Wang H, Liu Y, Sui Y, Wang W, Wang A, Xiao F, Giovannoni J, Liu Y. Ubiquitin-conjugated degradation of golden 2-like transcription factor is mediated by CUL4-DDB1-based E3 ligase complex in tomato. New phytologist. 2016, 209(3):1028-1039. (*共同第一作者)

4. Miao M, Zhu Y, Qiao M, Tang X, Zhao W, Xiao F, Liu Y.  The tomato DWD motif-containing protein DDI1 interacts with the CUL4-DDB1-based ubiquitin ligase and plays a pivotal role in abiotic stress responses. Biochemical and Biophysical Research Communication, 2014, 450(4):1439-1445.

5. Huang W*, Miao M*, Kud J, Niu X, Ouyang B, Zhang J, Ye Z, Kuhl JC, Liu Y, Xiao F. SlNAC1, a stress-related transcription factor, is fine-tuned on both the transcriptional and the post-translational level. New Phytologist, 2013, 197(4):1214-1224. (*共同第一作者)

6. Du X, Miao M, Ma X, Liu Y, Kuhl JC, Martin GB, Xiao F. Plant programmed cell death caused by an autoactive form of Prf is suppressed by co-expression of the Prf LRR domain. Molecular Plant, 2012, 5(5): 1058-1067.

7. Liu J, Li H, Miao M, Tang X, Giovannoni J, Xiao F, Liu Y. The tomato UV-damaged DNA-binding protein-1 (DDB1) is implicated in pathogenesis-related (PR) gene expression and resistance to Agrobacterium tumefaciens. Molecular Plant Pathology. 2012, 13(2): 123-34.

8. Zhu Y*, Huang S*, Miao M, Tang X, Yue J, Wang W, Liu Y. Genome-wide identification, sequence characterization, and protein-protein interaction properties of DDB1 (damaged DNA binding protein-1)-binding WD40-repeat family members in Solanum lycopersicum. Planta. 2015, 241(6):1337-1350.

9. Yue J, Xu W, Ban R, Huang S, Miao M, Tang X, Liu G, Liu Y. PTIR: Predicted Tomato Interactome Resource. Scientific Report. 2016 Apr 28;6:25047. doi: 10.1038/srep25047.

10. Gao L, Yang S, Zhu Y, Zhang J, Zhuo M, Miao M, Tang X, Liu Y*, Wang S*. The tomato DDI2, a PCNA ortholog, associating with DDB1-CUL4 complex is required for UV-damaged DNA repair and plant tolerance to UV stress. Plant Science. 2015, 235: 101-110.

11. Huang S, Ding J, Deng D, Tang W, …,Miao M, et al. Draft genome of the Kiwifruit Actinidia chinensis. Nature Communications. 2013, 4:2640 doi: 10.1038/ncomms3640.

12. Tang X*, Liu J*, Huang S, Shi W, Tang D, Niu X, Miao M, Xiao F, Liu Y. Roles of UV-damaged DNA binding protein 1 (DDB1) in epigenetically modifying multiple traits of agronomic importance in tomato. Plant signaling & behavior. 2012, 7(12): 1529-1532.

13. Liu J*, Tang X*, Gao L*, Gao Y, Li Y, Huang S, Sun X, Miao M, Zeng H, Tian X, Niu X, Zheng L, Giovannoni J, Xiao F, Liu Y. A Role of Tomato UV-Damaged DNA Binding Protein 1 (DDB1) in Organ Size Control via an Epigenetic Manner. PLoS One. 2012, 7(8): e42621.

在研项目

1. 主持博士后面上资助,《甲基转移酶SET作为E3泛素连接酶的底物调控细胞周期》,项目编号2014M561814

2. 主持中央高校基本科研业务费资助项目《泛素连接酶复合体CUL4-DDB1与底物转录因子NAC参与植物免疫应答的分子机理》

3. 参与国家自然科学基金青年基金,项目编号31300225,《共功能分析H2S调控拟南芥过氧化物酶H2O2接到的防御响应》

4. 参与国际合作项目,项目编号31461143008,《腐生病原真菌扩展青霉素penicillium expansum的效应蛋白挖掘及其功能鉴定》

 5. 参与国家自然科学基金面上项目,项目编号31471157,《猕猴桃维生素C高效合成与积累的分子机理研究》

6. 参与国家自然科学基金青年基金,项目编号31500214,《番茄DDB1与ATR激酶互作参与基础免疫应答的分子机理研究》

联系方式

升华楼229,minmiao@hfut.edu.cn