吴泽宇

发布日期:2016-09-30

吴泽宇

助理研究员,博士

个人简历

一、教育背景

2002.09~2006.06 合肥工业大学、生物技术专业,理学学士;

2006.09~2012.06 合肥工业大学、农产品加工及贮藏工程专业,工学博士;

二、工作经历

2012.06至今 工作于合肥工业大学农产品生物化工教育部工程研究中心

主要研究领域与方向

农产品精深加工 、天然产物开发

开设课程

《农产品加工系统工程》、《食品资源综合利用》硕士生课程

代表性论文、著作与专利

1. Wencheng Zhang, Qing Zhang, Xingyuan Zhang, Zeyu Wu, Bing Li, Xiuli Dong and Bingsong Wang. Preparation and evaluation of molecularly imprinted composite membranes for inducing crystallization of oleanolic acid in supercritical CO2 [J]. Analytical Methods, 2016.(通讯作者)

2. An Zhou, Zeyu Wu, Ailing Hui, Bin Wang, Xianchun Duan, Haixiang Wang and Jian Pan. 3D-QSAR and Molecular Docking Studies of Flavonoid Derivatives as Potent Acetylcholinesterase Inhibitors [J]. Letters in Drug Design & Discovery, 2015, 12: 837-843(共同一作).

3. Zeyu Wu, Jian Pan, Yuan Yuan, Ai-Ling Hui, Yi Yang, An Zhou, Min Tao, XiaoJian Zhou. Brain-targeting research of 10-O-nicotinate ginkgolide B: a new prodrug of ginkgolide B [J]. Medicinal Chemistry Research, 2012, 21(12): 4028-4036.

4. Zeyu Wu, Jian Pan, Yuan Yuan, Ai-Ling Hui, Yi Yang, An Zhou. Comparison of prediction models for blood brain barrier permeability and analysis of the molecular descriptors [J]. Die Pharmazie, 2012, 67(7): 628-634.

5. Jian Pan, Zeyu Wu, Yuan Yuan, Ailing Hui, Yi Yang. Simultaneous Determination of Prodrug of Ginkgolide B and Ginkgolide B in Rat Plasma by LC-MS/MS [J]. Latin American Journal of Pharmacy, 2011, 30(6): 1167-1172.

6. Huixi Bian, Zeyu Wu, Bin Bao, Jing Cai, Xin Wang, Ying Jiang, Jian Liu and Wei Qu. 1H NMR-based metabolic study reveals the improvements of bitter melon (Momordica charantia) on energy metabolism in diet-induced obese mouse [J]. Pharmaceutical Biology, 2016, 1-10.

7. Juan Liang, Jian Pan, Zeyu Wu, Mei Ge, Jinfeng Xu. Effects of high pressure in association with pH and salt on the allergenicity, proteolytic and fibrinolytic activities of pineapple juice [J]. Quality Assurance and Safety of Crops & Foods , 2016, 8(3):319-326.

8. Ailing Hui, Zeyu Wu, Yuan Yuan, An Zhou, Jian Pan. Progress in Synthesis and Antagonistic Activities towards PAFR and GlyR of Ginkgolide Derivatives and Analogs [J]. Chinese Journal of Organic Chemistry, 2013, 33(6): 1263-1272.

9. Yuan Yuan, Jian Pan, Zeyu Wu, Ailing Hui, An Zhou. Validated LC-MS-MS Method for the Determination of Prodrug of Ginkgolide B in Rat Plasma and Brain: Application to Pharmacokinetic Study [J]. Journal of Chromatographic Science, 2013, 51(3): 266-272.

10. An Zhou, Hongfei Wu, Jian Pan, Xuncui Wang, Jiaming Li, Zeyu Wu, Ailing Hui. Synthesis and evaluation of paeonol derivatives as potential multifunctional agents for the treatment of Alzheimer’s Disease [J]. Molecules, 2015, 20(1): 1304-1318.

11. An Zhou, Jianping Hu, Lirong Wang, Guochen Zhong, Jian Pan, Zeyu Wu, Ailing Hui. Combined 3D-QSAR, molecular docking and molecular dynamics study of tacrine derivatives as potential acetylcholinesterase (AChE) inhibitors of Alzheimer's disease [J]. Journal of Molecular Modeling, 2015, 21(10): 1-12.

12. Shuang-jie Zhu, Jian Pan, Bin Zhao, Juan Liang, Ze-yu Wu , Jun-jie Yang. Comparisons on enhancing the immunity of fresh and dryCordyceps militaris in vivo and in vitro [J]. Journal of Ethnopharmacology 2013, 149(3): 713–719.

在研项目

① 安徽大学现代生物制造协同中心开放课题,基于磁性Fe3O4和转铁蛋白的银杏内酯B双靶向纳米脂质体的制备及脑靶向性评价,2016/01-2016/12,在研,主持。

② 安徽省热敏性物料加工工程技术研究中心开放基金,滁菊中生物活性成分的综合提取工艺研究,2016/01-2016/12,在研,主持。

③ 国家自然科学基金青年基金项目(编号21501039),复合磁性纳米氧化物的制备与肝癌靶向诊疗一体化的研究,2016/01-2018/12,在研,参加。

④ 国家自然科学基金青年基金项目(编号21302037),P-糖蛋白抑制载体调控丹参素前药设计及脑靶向给药的研究,2014/01-2016/12,在研,参加。